Coronary Artery Disease Research Paper Example | Topics and Well Written Essays - 250 words

Coronary Artery Disease - Research Paper ExampleIt is established that LDL or Low-density lipoproteins are chiefly atherogenic in nature. On the other hand high-density lipoproteins or HDLs are defensive lipids as they aid in LDL metabolism. On oxidation LDLs endure tougher to metabolize and become cytotoxic leading to endothelial injury (Pollard, 2009).Chronic Endothelial injury Hypothesis- Endothelium protection and its repair is performed by glycosaminoglycan or GAGs, when GAGs become weak, atherosclerosis is instigated. The process is promoted out-of-pocket to exposure of endothelial cells and free-radical damage. As damage of endothelial lining is initiated the site promotes the permeability of plasma constituents especially the lipoproteins. Thus oxidized LDLs are capable of change the endothelial lining of the cells which results in the formation of plaque (Stephen, 2011).When the endothelial cells are injured, the macrophages present in the blood move around from the blood circulation. The inner positioning of the artery forms a layer called layer of intima. Consequently, smooth muscles join intima along with connective tissue as well as lipids present inside as well as outside the cells to generate a plaque. This brings about union as well as accumulation of platelets, as well as force out various growth regulating factors to amplify the procedure ensuing obstruction of the lumen of the artery, leading to thrombus establishment (Mottillo, 2010).Mottillo, S., Filion, K. B., Genest, J., Joseph, L., Pilote, L., Poirier, P., Rinfret, S., Schiffrin, E. L., Eisenberg, M. J. (2010). The Metabolic Syndrome and Cardiovascular Risk A imperious Review and Meta-Analysis. J. Am. Coll. Cardiol, 56(14), 1113- 1132.Stephen D. Wiviott, Marcus D. Flather, Michelle L. ODonoghue, Shinya Goto, Desmond J. Fitzgerald, Fernando Cura, Philip Aylward, Victor Guetta, Dariusz Dudek, Charles F. Contant, Dominick J. Angiolillo, Deepak L. Bhatt.